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Ämnesområden
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Ämnesområden
Arbetsrelaterat Shift work at young age is associated with increased risk for multiple sclerosis. Hedström AK, Åkerstedt T, Hillert J, Olsson T, Alfredsson L. Ann Neurol. 2011 Nov;70(5):733-41. doi: 10.1002/ana.22597. Epub 2011 Oct 17. Organic solvents and MS susceptibility: Interaction with MS risk HLA genes. Hedström AK, Hössjer O, Katsoulis M, Kockum I, Olsson T, Alfredsson L. Neurology. 2018 Jul 31;91(5):e455-e462. doi: 10.1212/WNL.0000000000005906. Epub 2018 Jul 3.
EBV Lack of replication of interaction between EBNA1 IgG and smoking in risk for multiple sclerosis. Sundqvist E, Sundström P, Lindén M, Hedström AK, Aloisi F, Hillert J, Kockum I, Alfredsson L, Olsson T. Neurology. 2012 Aug 29. [Epub ahead of print] Epstein-Barr virus and multiple sclerosis: interaction with HLA. Sundqvist E, Sundström P, Lindén M, Hedström AK, Aloisi F, Hillert J, Kockum I, Alfredsson L, Olsson T. Genes Immun. 2012 Jan;13(1):14-20. doi: 10.1038/gene.2011.42. Epub 2011 Jul 21. Rökning Marabita F, Almgren M, Sjöholm LK, Kular L, Liu Y, James T, Kiss NB, Feinberg AP, Olsson T, Kockum I, Alfredsson L, Ekström TJ, Jagodic M. Sci Rep. 2017 Nov 6;7(1):14589. doi: 10.1038/s41598-017-14788-w. Erratum in: Sci Rep. 2018 Mar 7;8(1):4340. The interaction between smoking and HLA genes in multiple sclerosis: replication and refinement. Hedström AK, Katsoulis M, Hössjer O, Bomfim IL, Oturai A, Sondergaard HB, Sellebjerg F, Ullum H, Thørner LW, Gustavsen MW, Harbo HF, Obradovic D, Gianfrancesco MA, Barcellos LF, Schaefer CA, Hillert J, Kockum I, Olsson T, Alfredsson L. Eur J Epidemiol. 2017 Oct;32(10):909-919. doi: 10.1007/s10654-017-0250-2. Epub 2017 Jun 8. Smoking is a major preventable risk factor for multiple sclerosis. Hedström AK, Olsson T, Alfredsson L. Mult Scler. 2016 Jul;22(8):1021-6. doi: 10.1177/1352458515609794. Epub 2015 Oct 12 Exposure to environmental tobacco smoke is associated with increased risk for multiple sclerosis. Hedström AK, Bäärnhielm M, Olsson T, Alfredsson L. Mult Scler. 2011 Jul;17(7):788-93. Epub 2011 Mar 3. Smoking and two human leukocyte antigen genes interact to increase the risk for multiple sclerosis. Hedström AK, Sundqvist E, Bäärnhielm M, Nordin N, Hillert J, Kockum I, Olsson T, Alfredsson L. Brain. 2011 Mar;134(Pt 3):653-64. Epub 2011 Feb 8 Tobacco smoking, but not Swedish snuff use, increases the risk of multiple sclerosis. Hedström AK, Bäärnhielm M, Olsson T, Alfredsson L. Neurology. 2009 Sep 1;73(9):696-701.
Vitamin D och solljus Evidence for a causal relationship between low vitamin D, high BMI, and pediatric-onset MS. Gianfrancesco MA, Stridh P, Rhead B, Shao X, Xu E, Graves JS, Chitnis T, Waldman A, Lotze T, Schreiner T, Belman A, Greenberg B, Weinstock-Guttman B, Aaen G, Tillema JM, Hart J, Caillier S, Ness J, Harris Y, Rubin J, Candee M, Krupp L, Gorman M, Benson L, Rodriguez M, Mar S, Kahn I, Rose J, Roalstad S, Casper TC, Shen L, Quach H, Quach D, Hillert J, Bäärnhielm M, Hedstrom A, Olsson T, Kockum I, Alfredsson L, Metayer C, Schaefer C, Barcellos LF, Waubant E; Network of Pediatric Multiple Sclerosis Centers. Neurology. 2017 Apr 25;88(17):1623-1629. doi: 10.1212/WNL.0000000000003849. Epub 2017 Mar 29. Mendelian randomization shows a causal effect of low vitamin D on multiple sclerosis risk. Rhead B, Bäärnhielm M, Gianfrancesco M, Mok A, Shao X, Quach H, Shen L, Schaefer C, Link J, Gyllenberg A, Hedström AK, Olsson T, Hillert J, Kockum I, Glymour MM, Alfredsson L, Barcellos LF. Neurol Genet. 2016 Sep 13;2(5):e97. doi: 10.1212/NXG.0000000000000097. eCollection 2016 Oct. Bäärnhielm M, Hedström AK, Kockum I, Sundqvist E, Gustafsson SA, Hillert J, Olsson T, Alfredsson L. Eur J Neurol. 2012 Jan 31. doi: 10.1111/j.1468-1331.2011.03650.x. [Epub ahead of print]
BMI Gianfrancesco MA, Glymour MM, Walter S, Rhead B, Shao X, Shen L, Quach H, Hubbard A, Jónsdóttir I, Stefánsson K, Strid P, Hillert J, Hedström A, Olsson T, Kockum I, Schaefer C, Alfredsson L, Barcellos LF. Am J Epidemiol. 2017 Feb 1;185(3):162-171. doi: 10.1093/aje/kww120. Body mass index during adolescence, rather than childhood, is critical in determining MS risk. Hedström AK, Olsson T, Alfredsson L. Mult Scler. 2016 Jun;22(7):878-83. doi: 10.1177/1352458515603798. Epub 2015 Sep 11. Hedström AK, Olsson T, Alfredsson L. Mult Scler. 2012 Feb 10. [Epub ahead of print]
Genetiska markörer Genetic risk factors for pediatric-onset multiple sclerosis. Gianfrancesco MA, Stridh P, Shao X, Rhead B, Graves JS, Chitnis T, Waldman A, Lotze T, Schreiner T, Belman A, Greenberg B, Weinstock-Guttman B, Aaen G, Tillema JM, Hart J, Caillier S, Ness J, Harris Y, Rubin J, Candee M, Krupp L, Gorman M, Benson L, Rodriguez M, Mar S, Kahn I, Rose J, Roalstad S, Casper TC, Shen L, Quach H, Quach D, Hillert J, Hedstrom A, Olsson T, Kockum I, Alfredsson L, Schaefer C, Barcellos LF, Waubant E; Network of Pediatric Multiple Sclerosis Centers. Mult Scler. 2017 Oct 1:1352458517733551. doi: 10.1177/1352458517733551. [Epub ahead of print] Interactions between genetic, lifestyle and environmental risk factors for multiple sclerosis. Olsson T, Barcellos LF, Alfredsson L. Nat Rev Neurol. 2017 Jan;13(1):25-36. doi: 10.1038/nrneurol.2016.187. Epub 2016 Dec 9. Review. Parsa R, Lund H, Tosevski I, Zhang XM, Malipiero U, Beckervordersandforth J, Merkler D, Prinz M, Gyllenberg A, James T, Warnecke A, Hillert J, Alfredsson L, Kockum I, Olsson T, Fontana A, Suter T, Harris RA. Glia. 2016 Nov;64(11):1925-37. doi: 10.1002/glia.23033. Epub 2016 Aug 1. Environmental factors and their interactions with risk genotypes in MS susceptibility. Hedström AK, Alfredsson L, Olsson T. Curr Opin Neurol. 2016 Jun;29(3):293-8. doi: 10.1097/WCO.0000000000000329. Review. Anoctamin 2 identified as an autoimmune target in multiple sclerosis. Ayoglu B, Mitsios N, Kockum I, Khademi M, Zandian A, Sjöberg R, Forsström B, Bredenberg J, Lima Bomfim I, Holmgren E, Grönlund H, Guerreiro-Cacais AO, Abdelmagid N, Uhlén M, Waterboer T, Alfredsson L, Mulder J, Schwenk JM, Olsson T, Nilsson P. Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2188-93. doi: 10.1073/pnas.1518553113. Epub 2016 Feb 9. Malmeström C, Gillett A, Jernås M, Khademi M, Axelsson M, Kockum I, Mattsson N, Zetterberg H, Blennow K, Alfredsson L, Wadenvik H, Lycke J, Olsson T, Olsson B. Mult Scler. 2012 Oct 4. [Epub ahead of print] Link J, Kockum I, Lorentzen AR, Lie BA, Celius EG, Westerlind H, Schaffer M, Alfredsson L, Olsson T, Brynedal B, Harbo HF, Hillert J. PLoS One. 2012;7(5):e36779. Epub 2012 May 7. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. International Multiple Sclerosis Genetics Consortium; Wellcome Trust Case Control Consortium 2, Sawcer S, Hellenthal G, Pirinen M et al Nature. 2011 Aug 10;476(7359):214-9. doi: 10.1038/nature102 No evidence of IL21 association with multiple sclerosis in a Swedish population. Lindén M, Nohra R, Sundqvist E, Khademi M, Hillert J, Alfredsson L, Olsson T, Kockum I. Tissue Antigens. 2011 Oct;78(4):271-4. doi: 10.1111/j.1399-0039.2011.01734.x. Epub 2011 Jul 8.
RGMA and IL21R show association with experimental inflammation and multiple sclerosis. Nohra R, Beyeen AD, Guo JP, Khademi M, Sundqvist E, Hedreul MT, Sellebjerg F, Smestad C, Oturai AB, Harbo HF, Wallström E, Hillert J, Alfredsson L, Kockum I, Jagodic M, Lorentzen J, Olsson T. Genes Immun. 2010 Jun;11(4):279-93. Epub 2010 Jan 14. Confirmation of association between multiple sclerosis and CYP27B1. Sundqvist E, Bäärnhielm M, Alfredsson L, Hillert J, Olsson T, Kockum I. Eur J Hum Genet. 2010 Dec;18(12):1349-52. Epub 2010 Jul 21. HLA-DRB1 and month of birth in multiple sclerosis. Ramagopalan SV, Link J, Byrnes JK, Dyment DA, Giovannoni G, Hintzen RQ, Sundqvist E, Kockum I, Smestad C, Lie BA, Harbo HF, Padyukov L, Alfredsson L, Olsson T, Sadovnick AD, Hillert J, Ebers GC. Neurology. 2009 Dec 15;73(24):2107-11. International Multiple Sclerosis Genetics Consortium. PLoS One. 2011 Apr 28;6(4):e18813. IL12A, MPHOSPH9/CDK2AP1 and RGS1 are novel multiple sclerosis susceptibility loci. International Multiple Sclerosis Genetics Conssortium (IMSGC). Genes Immun. 2010 Jul;11(5):397-405. Epub 2010 Jun 17.
Hedström AK, Mowry EM, Gianfrancesco MA, Shao X, Schaefer CA, Shen L, Olsson T, Barcellos LF, Alfredsson L. J Neurol Neurosurg Psychiatry. 2016 May;87(5):454-60. doi: 10.1136/jnnp-2015-312176. Epub 2016 Mar 3. |
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